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Jun Ishikawa Selected Research

4- methyl- 4'- (3,5- bis(trifluoromethyl)- 1H- pyrazol- 1- yl)- 1,2,3- thiadiazole- 5- carboxanilide

12/2008Characterization of YM-58483/BTP2, a novel store-operated Ca2+ entry blocker, on T cell-mediated immune responses in vivo.
1/2008The suppressive effects of YM-58483/BTP-2, a store-operated Ca2+ entry blocker, on inflammatory mediator release in vitro and airway responses in vivo.
4/2007YM-58483, a selective CRAC channel inhibitor, prevents antigen-induced airway eosinophilia and late phase asthmatic responses via Th2 cytokine inhibition in animal models.
5/2003A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes.

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Jun Ishikawa Research Topics

Disease

13Neoplasms (Cancer)
01/2022 - 09/2004
6BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
08/2022 - 06/2009
6Graft vs Host Disease (Graft-Versus-Host Disease)
12/2021 - 11/2006
4Inflammation (Inflammations)
01/2016 - 05/2003
4Asthma (Bronchial Asthma)
12/2008 - 07/2004
3Bronchiolitis Obliterans Syndrome
12/2021 - 01/2020
3Multiple Myeloma
08/2021 - 05/2018
3Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
08/2021 - 01/2020
3Hematologic Neoplasms (Hematological Malignancy)
05/2021 - 05/2013
3Rheumatoid Arthritis
02/2016 - 12/2008
3Eosinophilia
11/2008 - 04/2007
3Leukemia
01/2008 - 06/2003
3Mycetoma
06/2006 - 12/2004
2Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated)
11/2022 - 02/2012
2Cardiotoxicity
08/2021 - 05/2021
2Primary Myelofibrosis (Myelosclerosis)
01/2020 - 01/2019
2Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
12/2019 - 06/2009
2Arthritis (Polyarthritis)
02/2016 - 01/2016
2Sleep Initiation and Maintenance Disorders (Insomnia)
12/2015 - 05/2015
2Lymphoma (Lymphomas)
01/2013 - 11/2008
2Autoimmune Diseases (Autoimmune Disease)
12/2008 - 05/2003
2Hypersensitivity (Allergy)
12/2008 - 05/2003
2Respiratory Hypersensitivity
08/2008 - 01/2008
2Hepatitis
07/2006 - 09/2003
1Infections
03/2022
1Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral)
01/2022
1T-Cell Lymphoma (Lymphoma, T Cell)
01/2022
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
09/2021
1Non-Hodgkin Lymphoma (Lymphosarcoma)
08/2021
1Febrile Neutropenia
01/2021
1Peri-Implantitis
01/2021
1Polycythemia Vera
01/2020
1Essential Thrombocythemia
01/2020
1Refractory Anemia
10/2018
1Paralysis (Palsy)
10/2018
1Myelodysplastic Syndromes (Myelodysplastic Syndrome)
10/2018
1Transient Ischemic Attack
10/2017
1Pathologic Constriction (Stenosis)
10/2017
1Hyperbilirubinemia
10/2017
1Cardiovascular Diseases (Cardiovascular Disease)
10/2017
1Stroke (Strokes)
10/2017
1Atherosclerosis
10/2017
1Peripheral Arterial Occlusive Disease 1
10/2017
1Hyperglycemia
10/2017
1Dental Caries (Decay, Dental)
08/2016
1Experimental Arthritis
01/2016
1Feeding and Eating Disorders (Eating Disorder)
01/2016

Drug/Important Bio-Agent (IBA)

5Pharmaceutical PreparationsIBA
03/2022 - 09/2004
4Tyrosine Kinase InhibitorsIBA
08/2022 - 09/2014
44- methyl- 4'- (3,5- bis(trifluoromethyl)- 1H- pyrazol- 1- yl)- 1,2,3- thiadiazole- 5- carboxanilideIBA
12/2008 - 05/2003
4AntigensIBA
12/2008 - 07/2004
3Anti-Bacterial Agents (Antibiotics)IBA
08/2021 - 12/2004
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
08/2021 - 05/2013
3nilotinibFDA Link
12/2019 - 06/2009
3Imatinib Mesylate (Gleevec)FDA Link
10/2017 - 06/2009
3Hypnotics and Sedatives (Sedatives)IBA
01/2016 - 05/2015
3CytokinesIBA
12/2008 - 04/2007
2Interleukin-2 Receptors (IL 2 Receptor)IBA
08/2021 - 01/2020
2Lenalidomide (CC 5013)FDA Link
08/2021 - 05/2021
2Melphalan (Alkeran)FDA LinkGeneric
11/2020 - 12/2019
2OvalbuminIBA
11/2008 - 08/2008
2Calcium Release Activated Calcium ChannelsIBA
04/2007 - 07/2006
2transvalencin AIBA
12/2004 - 12/2004
2limitinIBA
09/2004 - 09/2003
1SterolsIBA
03/2022
1Antilymphocyte Serum (Anti-Thymocyte Globulin)IBA
12/2021
1Rituximab (Mabthera)FDA Link
09/2021
1AnthracyclinesIBA
08/2021
1Vincristine (Oncovin)FDA LinkGeneric
08/2021
1Doxorubicin (Adriamycin)FDA LinkGeneric
08/2021
1Prednisone (Sone)FDA LinkGeneric
08/2021
1pirarubicinIBA
08/2021
1Dental Implants (Dental Implant)IBA
01/2021
1fludarabineIBA
11/2020
1Busulfan (Busulfex)FDA Link
11/2020
1Tacrolimus (Prograf)FDA LinkGeneric
02/2020
1Methotrexate (Mexate)FDA LinkGeneric
02/2020
1HLA Antigens (Human Leukocyte Antigens)IBA
01/2019
1Acyclovir (Aciclovir)FDA LinkGeneric
10/2018
1Azacitidine (5 Azacytidine)FDA Link
10/2018
1Dexamethasone (Maxidex)FDA LinkGeneric
05/2018
1pomalidomideIBA
05/2018
1EnzymesIBA
10/2017
1PectinsIBA
08/2016
1TeaIBA
08/2016
1Collagen Type II (Type II Collagen)IBA
02/2016
1Conditioned Culture MediaIBA
02/2016
1LectinsIBA
01/2016

Therapy/Procedure

7Bone Marrow Transplantation (Transplantation, Bone Marrow)
01/2021 - 05/2002
6Transplantation
11/2022 - 05/2013
6Drug Therapy (Chemotherapy)
01/2022 - 01/2013
6Therapeutics
08/2021 - 01/2009
5Hematopoietic Stem Cell Transplantation
01/2022 - 09/2014
5Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation)
12/2021 - 02/2012
5Cell Transplantation
01/2021 - 01/2009
3Stem Cell Transplantation
08/2022 - 05/2013
3Homologous Transplantation
12/2019 - 06/2003
1Oral Hygiene (Dental Hygiene)
01/2021
1Stents
10/2017
1Intravenous Administration
02/2016